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Isovolemic hemodilution has been reported to increase cerebral perfusion in humans and has been advocated as a treatment for acute cerebral infarction. This study examines the effect of isovolemic hemodilution with low-molecular-weight dextran on mortality and the incidence of neurological deficit in gerbils after internal carotid ligation. Sixty-four Mongolian gerbils were anesthetized with pentobarbital and the left internal carotid artery was ligated in both control and experimental animals. In the experimental group, blood was removed and an equal volume of dextran was injected to reestablish normal blood volume and lower hematocrit to a mean of 30.5. Control animals were not so treated. Animals were observed for neurological deficits for 24 hours after carotid ligation. The incidence of neurological deficit in control animals was 67%; it was 64% in the experimental group. Mortality within the first 24 hours was 28% in the controls and 75% in animals that were treated by hemodilution (p less than 0.001). Isovolemic hemodilution with dextran did not reduce the incidence of neurological deficit after carotid ligation in gerbils and was associated with a significant increase in mortality during the first 24 hours.
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
January 1996,
Romanian journal of internal medicine = Revue roumaine de medecine interne,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
January 1994,
Anesteziologiia i reanimatologiia,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
April 1990,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
January 1993,
Beitrage zur Infusionstherapie = Contributions to infusion therapy,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
August 1991,
American journal of surgery,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
August 1995,
Transfusion,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
January 1979,
Beitrage zu Infusionstherapie und klinische Ernahrung,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
May 1976,
Medizinische Monatsschrift,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
January 1987,
Progress in clinical and biological research,
J P Kapp, and
R R Smith, and
D F Peeler, and
S Morrow, and
E S Smith
October 1986,
Deutsche medizinische Wochenschrift (1946),
