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Synthesis of Cyclic α-Aminophosphonates through Copper Catalyzed Enamine Activation. 2013

Junbin Han, and Robert S Paton, and Bo Xu, and Gerald B Hammond
Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.

A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic α-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed.

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