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Platelet-activating factor (PAF) was found to induce histamine release from human basophils in mixed leukocytes in the presence of cytochalasin B. The reaction was rapid and dependent on temperature. The release was lower at a high concentration of PAF and was inhibited by EDTA, suggesting a noncytolytic mechanism. CV-3988, a PAF antagonist, inhibited the reaction dose-dependently. PAF acted as an IgE-independent stimulus, but PAF-induced histamine release from leukocytes of allergic asthmatics, who had elevated serum IgE levels, was significantly higher than that from leukocytes of controls. These results suggest that PAF-induced histamine release is useful for studying the role of PAF in the pathogenesis of allergic disorders including bronchial asthma.
Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
March 1994,
Arerugi = [Allergy],
Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
January 1993,
International archives of allergy and immunology,
Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
July 1990,
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Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
January 1992,
International archives of allergy and immunology,
Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
January 1981,
Scandinavian journal of immunology,
Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
October 1983,
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Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
January 1987,
Agents and actions. Supplements,
Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
April 1990,
Agents and actions,
Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
January 1977,
International archives of allergy and applied immunology,
Y Okuda, and
I Tsuyuguchi, and
A Yamatodani
May 1990,
Arerugi = [Allergy],
