BIOMAT Database Logo BIOMAT Database Logo

Dextromethorphan and dextrorphan as calcium channel antagonists. 1988

C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Department of Neurology, University of California, San Francisco 94110.

Dextromethorphan and dextrorphan, which reduce excitatory amino acid-induced neurotoxicity, decreased K+ depolarization-evoked 45Ca2+ uptake into brain synaptosomes and cultured neural (PC12) cells. Half-maximal inhibition of synaptosomal 45Ca2+ uptake occurred with 48 microM dextromethorphan or 200 microM dextrorphan, which are similar to concentrations associated with protection from excitotoxicity. The ability to decrease Ca2+ flux through N-type (synaptosomal) and L-type (PC12) voltage-gated Ca2+ channels may therefore contribute to the neuroprotective effects of these compounds.

UI MeSH Term Description Entries
D007473 Ion Channels Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS. Membrane Channels,Ion Channel,Ionic Channel,Ionic Channels,Membrane Channel,Channel, Ion,Channel, Ionic,Channel, Membrane,Channels, Ion,Channels, Ionic,Channels, Membrane
D007700 Kinetics The rate dynamics in chemical or physical systems.
D007981 Levorphanol A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection. Levorphan,3-Hydroxy-N-methylmorphinan,L-Dromoran,Levo-Dromoran,Levodroman,Levorphanol Tartrate,3 Hydroxy N methylmorphinan,L Dromoran,Levo Dromoran,LevoDromoran,Tartrate, Levorphanol
D008297 Male Males
D009019 Morphinans Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS. Morphinan
D011188 Potassium An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002121 Calcium Channel Blockers A class of drugs that act by selective inhibition of calcium influx through cellular membranes. Calcium Antagonists, Exogenous,Calcium Blockaders, Exogenous,Calcium Channel Antagonist,Calcium Channel Blocker,Calcium Channel Blocking Drug,Calcium Inhibitors, Exogenous,Channel Blockers, Calcium,Exogenous Calcium Blockader,Exogenous Calcium Inhibitor,Calcium Channel Antagonists,Calcium Channel Blocking Drugs,Exogenous Calcium Antagonists,Exogenous Calcium Blockaders,Exogenous Calcium Inhibitors,Antagonist, Calcium Channel,Antagonists, Calcium Channel,Antagonists, Exogenous Calcium,Blockader, Exogenous Calcium,Blocker, Calcium Channel,Blockers, Calcium Channel,Calcium Blockader, Exogenous,Calcium Inhibitor, Exogenous,Channel Antagonist, Calcium,Channel Blocker, Calcium,Inhibitor, Exogenous Calcium

Related Publications

C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries.
October 2008, Journal of neurosurgical anesthesiology,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity.
February 1987, Brain research,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Lack of interaction of the NMDA receptor antagonists dextromethorphan and dextrorphan with P-glycoprotein.
February 2008, Current drug metabolism,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Pharmacokinetics of dextromethorphan and dextrorphan in epileptic patients.
January 1996, Acta neurologica Scandinavica,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Comparative antitussive effects of dextrorphan, dextromethorphan and phencyclidine.
July 1986, Arzneimittel-Forschung,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Dimeric 1,4-dihydropyridines as calcium channel antagonists.
August 1988, Journal of medicinal chemistry,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Dibenzothiazepinones as potential calcium channel antagonists. I.
January 1993, Drug design and discovery,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Calcium channel antagonists.
January 1994, Postgraduate medicine,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Calcium-channel antagonists.
August 1993, The Practitioner,
C L Carpenter, and S S Marks, and D L Watson, and D A Greenberg
Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance.
July 2005, Drug metabolism and disposition: the biological fate of chemicals,
Copied contents to your clipboard!