-transparent.png){kind=logo}
It is well established that angiotensin II (AII) rapidly increases free cytosolic Ca2+ in vascular smooth muscle cells (VSMCs). Several studies have indicated that the hormone also plays a role in Na+-K+ regulation of these cells. In this study, we explored the mechanism of AII effect on 22Na+ transport in cultured rat VSMCs. The 22Na+ washout from these cells was described by three exponents with exponential factors k1 greater than k2 greater than k3. In 1.8 mM Ca2+ medium, AII (10(-9)-10(-6) M) increased (in a dose response manner) the k1 value, and consequently the initial washout rate constant (kei) for the isotope. AII had no effect on kei in Ca2+-deficient medium or in the presence of ouabain. Amiloride (10(-3) M) and verapamil (10(-5) M) abolished the AII induced increase in kei. These findings are consistent with angiotensin II stimulation of an amiloride-sensitive Na+ transport, which is likely to represent the Na+/H+ antiport. In cultured VSMCs, the sustained stimulation by AII of this transport system requires the presence of extracellular Ca2+ and its influx into these cells.
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
October 1992,
The Journal of biological chemistry,
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
April 1987,
The Journal of biological chemistry,
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
January 1998,
Basic research in cardiology,
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
November 1995,
British journal of pharmacology,
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
July 1994,
The Journal of surgical research,
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
May 2005,
Molecular pharmacology,
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
October 1998,
Journal of cellular physiology,
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
March 2009,
Clinical science (London, England : 1979),
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
January 1999,
Journal of the American Society of Nephrology : JASN,
S Kuriyama, and
A Nakamura, and
L Hopp, and
B P Fine, and
M Kino, and
E Cragoe, and
A Aviv
December 1995,
Circulation research,
