BIOMAT Database Logo BIOMAT Database Logo

Distinctive patterns of release of neuroendocrine peptides after nasal challenge of allergic subjects with ryegrass antigen. 1988

K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Department of Pediatrics, University of California, San Francisco 94143.

The concentrations of the neuropeptides substance P, somatostatin, and calcitonin gene-related peptide in human nasal secretions were quantified by radioimmunoassays, concurrently with that of histamine, in the course of nasal challenge of allergic and control subjects with ryegrass antigen to examine contributions of neuromediation of the tissue response. Each of the neuropeptides and histamine were detected in nasal lavage fluid prior to challenge. In allergic patients, but not normal controls, antigen evoked significant increases of 3-fold in histamine at 15-60 min, 1.5- to 4-fold in calcitonin gene-related peptide at 15 min-24 hr, and more than 2-fold in somatostatin at 6 hr, without altering the concentration of substance P in nasal lavage fluid. The identity of the neuropeptides was confirmed chromatographically. Thus calcitonin gene-related peptide may mediate nasal congestion directly and somatostatin may be one of the factors regulating the late involvement of basophils and mast cells in allergic rhinitis.

UI MeSH Term Description Entries
D008129 Lolium Common member of the Gramineae family used as cattle FODDER. It harbors several fungi and other parasites toxic to livestock and people and produces allergenic compounds, especially in its pollen. The most commonly seen varieties are L. perenne, L. multiflorum, and L. rigidum. Ryegrass,Rye Grass,Grass, Rye
D008297 Male Males
D009297 Nasal Mucosa The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells. Nasal Epithelium,Schneiderian Membrane,Epithelium, Nasal,Membrane, Schneiderian,Mucosa, Nasal
D009330 Nebulizers and Vaporizers Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments. Atomizers,Inhalation Devices,Inhalators,Inhalers,Vaporizers,Nebulizers,Vaporizers and Nebulizers,Atomizer,Device, Inhalation,Devices, Inhalation,Inhalation Device,Inhalator,Inhaler,Nebulizer,Vaporizer
D009479 Neuropeptides Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells. Neuropeptide
D005260 Female Females
D006255 Rhinitis, Allergic, Seasonal Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS. Hay Fever,Pollen Allergy,Pollinosis,Seasonal Allergic Rhinitis,Hayfever,Allergic Rhinitides, Seasonal,Allergic Rhinitis, Seasonal,Allergies, Pollen,Allergy, Pollen,Fever, Hay,Pollen Allergies,Pollinoses,Rhinitides, Seasonal Allergic,Rhinitis, Seasonal Allergic,Seasonal Allergic Rhinitides
D006636 Histamine Release The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects. Histamine Liberation,Histamine Liberations,Histamine Releases
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000281 Administration, Intranasal Delivery of medications through the nasal mucosa. Drug Administration, Intranasal,Administration, Intranasal Drug,Administration, Nasal,Intranasal Administration,Intranasal Drug Administration,Administrations, Intranasal,Administrations, Intranasal Drug,Administrations, Nasal,Drug Administrations, Intranasal,Intranasal Administrations,Intranasal Drug Administrations,Nasal Administration,Nasal Administrations

Related Publications

K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Effect of slow-release theophylline on nasal antigen challenge in subjects with allergic rhinitis.
May 1998, The European respiratory journal,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Proinflammatory cytokines in nasal secretions of allergic subjects after antigen challenge.
February 1994, American journal of respiratory and critical care medicine,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Effect of ozone inhalation on the response to nasal challenge with antigen of allergic subjects.
September 1990, The American review of respiratory disease,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Influx of kininogens into nasal secretions after antigen challenge of allergic individuals.
July 1985, The Journal of clinical investigation,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
[Kinins and kallikrein in nasal secretion after antigen challenge in patients with allergic rhinitis].
August 1994, Nihon Jibiinkoka Gakkai kaiho,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Physiologic responses and histamine release after nasal antigen challenge. Effect of atropine.
June 1994, American journal of respiratory and critical care medicine,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Tympanometric changes following nasal antigen challenge in children with allergic rhinitis.
December 1984, Annals of allergy,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Mediator release after nasal airway challenge with allergen.
October 1983, The American review of respiratory disease,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Mediator release after nasal airway challenge with allergen.
November 1986, The American review of respiratory disease,
K B Walker, and M H Serwonska, and F H Valone, and W S Harkonen, and O L Frick, and K H Scriven, and W D Ratnoff, and J G Browning, and D G Payan, and E J Goetzl
Histamine release after nasal challenge with anti-IgE and Staphylococcus aureus in patients with allergic rhinitis.
January 1992, Pneumonologia i alergologia polska,
Copied contents to your clipboard!