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High levels of ferritin have been detected in serum and tumoral extracts of gastrointestinal neoplasms. However, its histological localization is not well known. An immunoperoxidase technique (PAP) was used for detecting ferritin in 30 colorectal carcinomas, 20 polyps and 8 cases of non-neoplastic mucosae. Ferritin staining was detected in stromal cells (98%) much more than in epithelial cells (21%). Connective cells were positive in 5 cases of normal mucosae (62%), 19 polyps (95%) and all carcinomas (100%). The number of positive cells gradually rose from normal mucosa to carcinoma with an intermediate score in adenomas. However, no relation could be found between the stromal ferritin score and dysplasia in polyps. Likewise, no relation was found between the stromal ferritin score and the differentiation grade, invasion or metastases in carcinomas. The positive epithelial pattern seen in 12 cases (21%) suggests non-specific staining due to passive diffusion from the stroma. Thus, these immunohistochemical findings suggest that in colonic neoplasms, ferritin could be a tumor marker produced mainly by stromal cell reaction more than by the epithelial cells.
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
November 1990,
Journal of clinical pathology,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
March 1977,
Bollettino dell'Istituto sieroterapico milanese,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
January 2001,
Human pathology,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
January 1987,
Pathology annual,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
January 1998,
Anticancer research,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
October 1978,
Cancer research,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
July 1992,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
January 1981,
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
July 1987,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology,
E Campo, and
A Palacin, and
C Benasco, and
E Condom, and
A Cardesa
November 2005,
The Journal of clinical endocrinology and metabolism,
