-transparent.png){kind=logo}
Induction of 2'-5'-oligoadenylatesynthetase (2-5A synthetase) by interferons and theophylline by means of activation of cAMP-system in interferon susceptible and resistant cell lines were studied. In interferon resistant cell lines the basal activity of 2-5A synthetase exceeded the level of the same enzyme in interferon susceptible cell lines. Activity of 2-5A synthetase is increased in interferon susceptible cell lines by interferon treatment, but the activity of the enzyme is not altered in interferon resistant cell lines. Among the studied cell lines the induction of 2-5A synthetase by theophylline was possible only in L929 cell line. The common mechanism for the absence of 2-5A synthetase induction by interferon and theophylline in interferon resistant cells is discussed.
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
October 1978,
The Journal of general virology,
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
January 1996,
Biochemical pharmacology,
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
January 1985,
Progress in clinical and biological research,
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
January 1992,
Journal of biological regulators and homeostatic agents,
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
August 1968,
Biochemical pharmacology,
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
June 1969,
Science (New York, N.Y.),
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
May 1982,
Proceedings of the National Academy of Sciences of the United States of America,
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
March 1984,
Archiv fur experimentelle Veterinarmedizin,
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
January 1978,
Acta microbiologica Bulgarica,
A N Narovlianskiĭ, and
K T Turpaev, and
A M Amchenkova, and
A V Itkes, and
E G Alimov
December 1982,
International journal of cancer,
