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Four cases of clostridial myonecrosis that developed in open fractures were treated with surgical debridement and with intravenous cephalosporins as antibiotic prophylaxis. All patients recovered following amputation of the involved extremity, and treatment with high-dose penicillin in three cases, and erythromycin plus high-dose cephalothin in the fourth. This complication was not seen in patients with similar injuries that were managed surgically but used other antibiotics, usually penicillin, as prophylaxis. In vitro susceptibility tests of clostridia to cephalothin were performed; the results demonstrated that nearly 50% of clostridia tested were resistant to cephalothin.
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
January 2012,
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc,
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
January 1981,
Zentralblatt fur Chirurgie,
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
October 1973,
Clinical orthopaedics and related research,
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
January 1999,
Ryoikibetsu shokogun shirizu,
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
December 1952,
Antibiotics & chemotherapy (Northfield, Ill.),
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
January 1999,
Ryoikibetsu shokogun shirizu,
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
September 2000,
The Journal of infectious diseases,
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
January 1994,
Abdominal imaging,
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
January 1983,
Acta chirurgica Scandinavica,
J A Mohr, and
W Griffiths, and
R Holm, and
C Garcia-Moral, and
D J Flournoy
January 1990,
Instructional course lectures,
