ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe. 2014

Hein Sprong, and Jos Trentelman, and Ingar Seemann, and Libor Grubhoffer, and Ryan O M Rego, and Ondřej Hajdušek, and Petr Kopáček, and Radek Šíma, and Ard M Nijhof, and Juan Anguita, and Peter Winter, and Bjorn Rotter, and Sabina Havlíková, and Boris Klempa, and Theo P Schetters, and Joppe W R Hovius
The National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands. hein.sprong@rivm.nl.

Ixodes ricinus transmits bacterial, protozoal and viral pathogens, causing disease and forming an increasing health concern in Europe. ANTIDotE is an European Commission funded consortium of seven institutes, which aims to identify and characterize tick proteins involved in feeding and pathogen transmission. The knowledge gained will be used to develop and evaluate anti-tick vaccines that may prevent multiple human tick-borne diseases. Strategies encompassing anti-tick vaccines to prevent transmission of pathogens to humans, animals or wildlife will be developed with relevant stakeholders with the ultimate aim of reducing the incidence of tick-borne diseases in humans.

UI MeSH Term Description Entries
D005060 Europe The continent north of AFRICA, west of ASIA and east of the ATLANTIC OCEAN. Northern Europe,Southern Europe,Western Europe
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000931 Antidotes Agents counteracting or neutralizing the action of POISONS. Antidote,Theriacs
D013984 Tick Infestations Infestations with soft-bodied (Argasidae) or hard-bodied (Ixodidae) ticks. Infestation, Tick,Infestations, Tick,Tick Infestation
D013987 Ticks Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44) Ixodida,Ixodidas,Tick
D014612 Vaccines Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases. Vaccine
D017282 Tick-Borne Diseases Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic. Tick Borne Disease,Tick-Borne Infection,Infections, Tick-Borne,Tick-Borne Infections,Borne Disease, Tick,Borne Diseases, Tick,Disease, Tick Borne,Disease, Tick-Borne,Diseases, Tick Borne,Diseases, Tick-Borne,Infection, Tick-Borne,Infections, Tick Borne,Tick Borne Diseases,Tick Borne Infection,Tick Borne Infections,Tick-Borne Disease
D060829 Arthropod Proteins Proteins synthesized by organisms belonging to the phylum ARTHROPODA. Included in this heading are proteins from the subdivisions ARACHNIDA; CRUSTACEA; and HORSESHOE CRABS. Note that a separate heading for INSECT PROTEINS is listed under this heading. Arachnid Proteins,Crustacean Proteins,Horseshoe Crab Proteins,Spider Proteins,Tick Proteins

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