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In the assessment of response to treatment of ovarian cancer patients, clinical examination is unreliable in detecting small tumor masses. The second-look laparotomy is therefore an accepted procedure. The optimal timing of second-look laparotomy, however, is uncertain. We therefore examined the usefulness of serial serum CA-125 estimations in the timing of second-look laparotomies in 33 patients suffering from ovarian cancer. Increasing CA-125 concentrations were always followed by relapses or progressive disease, whereas decreasing serum concentrations indicated response to treatment. In future we propose to perform second-look laparotomies when CA-125 levels have declined to a steady plateau and to start a secondary treatment when CA-125 levels start to rise again.
W Jäger, and
R Adam, and
L Wildt, and
N Lang
December 1988,
European journal of cancer & clinical oncology,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
May 1986,
Obstetrics and gynecology,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
January 1997,
The Kurume medical journal,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
July 1992,
Gynecologic oncology,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
May 1988,
Geburtshilfe und Frauenheilkunde,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
February 1986,
American journal of obstetrics and gynecology,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
April 1985,
American journal of obstetrics and gynecology,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
March 1989,
Bailliere's clinical obstetrics and gynaecology,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
October 1989,
Gynecologic oncology,
W Jäger, and
R Adam, and
L Wildt, and
N Lang
January 1990,
European journal of gynaecological oncology,
