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Five human-human hybridoma cell lines secreting monoclonal antibodies (mAbs) against lipid A (LA) were produced by cell fusion of Epstein-Barr virus (EBV) transformed human peripheral blood lymphocytes and a human lymphoblastoid cell line KR-4. All these mAbs were isotyped as IgM(kappa) and reacted with lipopolysaccharides (LPS) and LA of various gram-negative bacteria. Whereas the binding of only four of the five mAbs to solid-phase LA was blocked by polymyxin-B sulphate, the mitogenic effect of LPS and LA on murine B lymphocytes was inhibited by all five mAbs. These results demonstrate that the human immune system recognizes at least two common epitopes in lipid A of various gram-negative bacteria.
R N Ramachandra, and
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A H Sehon
September 1988,
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R N Ramachandra, and
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April 1989,
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R N Ramachandra, and
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Cancer investigation,
R N Ramachandra, and
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April 1992,
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R N Ramachandra, and
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A H Sehon
March 1981,
Proceedings of the National Academy of Sciences of the United States of America,
R N Ramachandra, and
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July 1991,
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R N Ramachandra, and
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Experimental and clinical immunogenetics,
R N Ramachandra, and
I Berczi, and
A H Sehon
January 1986,
Medical microbiology and immunology,
R N Ramachandra, and
I Berczi, and
A H Sehon
January 1985,
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R N Ramachandra, and
I Berczi, and
A H Sehon
January 1995,
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