Painful neurological syndromes in cancer patients require comprehensive clinical assessment for their accurate diagnosis. Early diagnosis of the painful neurological syndromes in cancer patients allows the clinician to target his therapy toward preventing escalating pain, disability, and further neurological morbidity. Active rehabilitation is critically important in the management of these patients with neurological pain syndromes. Rehabilitation helps prevent further pain due to the development of secondary problems of immobility or disuse, helps the individual patient achieve his maximal level of functioning and helps each patient adapt to his/her neurological deficits.