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To examine the possible role of adenosine in the vasoactivity of acetate, acetate and adenosine were injected into the renal artery of the dog while measuring renal blood flow. Low (9-28 mg) doses of acetate produced vasodilation, but higher doses (28-94 mg), like adenosine, produced vasoconstriction followed by vasodilation. Theophylline, a competitive inhibitor of the vascular action of adenosine, inhibited the vasodilator action of adenosine but not that of acetate. Secondly, theophylline inhibited the vasoconstrictor effect of adenosine and acetate but the latter to a much lesser extent. These findings suggest that adenosine mediates the vasoconstriction effect of acetate in the canine kidney.
R P Steffen, and
J T O'Neill, and
F J Haddy
January 1972,
Acta physiologica Academiae Scientiarum Hungaricae,
R P Steffen, and
J T O'Neill, and
F J Haddy
December 1986,
The Journal of pharmacology and experimental therapeutics,
R P Steffen, and
J T O'Neill, and
F J Haddy
August 1989,
The American review of respiratory disease,
R P Steffen, and
J T O'Neill, and
F J Haddy
February 1989,
Annals of allergy,
R P Steffen, and
J T O'Neill, and
F J Haddy
February 2003,
Radiology,
R P Steffen, and
J T O'Neill, and
F J Haddy
January 1978,
Biochemical pharmacology,
R P Steffen, and
J T O'Neill, and
F J Haddy
January 1987,
The American journal of physiology,
R P Steffen, and
J T O'Neill, and
F J Haddy
January 1992,
International journal of tissue reactions,
R P Steffen, and
J T O'Neill, and
F J Haddy
January 1986,
Basic research in cardiology,
R P Steffen, and
J T O'Neill, and
F J Haddy
December 1974,
Cancer research,
