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Recombinant human IFN-gamma, used for treatment of melanoma and renal carcinoma, was found to induce HLA-DR expression on human keratinocytes in vivo. HLA-DR antigens bound to keratinocytes of the basal and suprabasal layers of the epidermis were observed after intramuscular or intravenous injections of 0.5 mg/kg body weight IFN-gamma, 3 times a week. Keratinocyte-bound HLA-DR antigens were first observed at the beginning of the third or fourth week of treatment, but HLA-DQ and HLA-DP antigens were never detected on keratinocytes. The intracytoplasmic constant (gamma) chain of the class II molecules was also not detectable within the keratinocytes. Patients who received IFN-alpha 2 therapy, did not exhibit keratinocyte-bound HLA-DR antigens.
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
May 1986,
European journal of immunology,
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
May 1988,
The Laryngoscope,
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
April 1983,
Journal of immunology (Baltimore, Md. : 1950),
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
April 1996,
Blood,
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
October 1986,
The American journal of pathology,
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
March 1990,
The American journal of pathology,
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
August 1984,
The Journal of investigative dermatology,
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
September 1983,
Clinical and experimental immunology,
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
October 1991,
Journal of interferon research,
B Volc-Platzer, and
A Steiner, and
T Radaszkiewicz, and
K Wolff
February 1985,
European journal of immunology,
