BIOMAT Database Logo BIOMAT Database Logo

Antihypertensive effect of felodipine or hydralazine when added to beta-blocker therapy. 1988

L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Department of Medicine, Ostra Hospital, Göteborg, Sweden.

In a double-blind randomized study, hydralazine (n = 59) or the new dihydropyridine calcium antagonist felodipine (n = 61) was added to previous treatment with beta-adrenoceptor blocking agents in a group of 120 patients with essential hypertension. Active treatment with either hydralazine or felodipine was given for 8 weeks after a 4-week placebo run-in period, at the end of which all patients had supine diastolic blood pressures greater than 95 mm Hg. Assessment of the results according to the intention to treat principle showed that felodipine was significantly more effective than hydralazine at the doses employed, reducing systolic blood pressure 10-19 mm Hg more than hydralazine and reducing diastolic blood pressure 5-11 mm Hg more than hydralazine (95% confidence intervals). The number of patients complaining of side effects, the number of complaints, and the number of patients that had to be withdrawn from treatment were numerically higher during treatment with hydralazine than with felodipine, but these differences were not statistically significant. Against this background it is concluded that felodipine is superior to hydralazine when added to an antihypertensive regimen consisting of beta-adrenoceptor blocking agents.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009568 Nitrendipine A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. Balminil,Bay e 5009,Bayotensin,Baypresol,Baypress,Gericin,Jutapress,Nidrel,Niprina,Nitre AbZ,Nitre-Puren,Nitregamma,Nitren 1A Pharma,Nitren Lich,Nitren acis,Nitrend KSK,Nitrendepat,Nitrendi Biochemie,Nitrendidoc,Nitrendimerck,Nitrendipin AL,Nitrendipin Apogepha,Nitrendipin Atid,Nitrendipin Basics,Nitrendipin Heumann,Nitrendipin Jenapharm,Nitrendipin Lindo,Nitrendipin Stada,Nitrendipin beta,Nitrendipin-ratiopharm,Nitrendipino Bayvit,Nitrendipino Ratiopharm,Nitrensal,Nitrepress,Tensogradal,Trendinol,Vastensium,nitrendipin von ct,nitrendipin-corax,Nitre Puren,NitrePuren,Nitrendipin ratiopharm,Nitrendipinratiopharm,nitrendipin corax,nitrendipincorax
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002121 Calcium Channel Blockers A class of drugs that act by selective inhibition of calcium influx through cellular membranes. Calcium Antagonists, Exogenous,Calcium Blockaders, Exogenous,Calcium Channel Antagonist,Calcium Channel Blocker,Calcium Channel Blocking Drug,Calcium Inhibitors, Exogenous,Channel Blockers, Calcium,Exogenous Calcium Blockader,Exogenous Calcium Inhibitor,Calcium Channel Antagonists,Calcium Channel Blocking Drugs,Exogenous Calcium Antagonists,Exogenous Calcium Blockaders,Exogenous Calcium Inhibitors,Antagonist, Calcium Channel,Antagonists, Calcium Channel,Antagonists, Exogenous Calcium,Blockader, Exogenous Calcium,Blocker, Calcium Channel,Blockers, Calcium Channel,Calcium Blockader, Exogenous,Calcium Inhibitor, Exogenous,Channel Antagonist, Calcium,Channel Blocker, Calcium,Inhibitor, Exogenous Calcium
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females

Related Publications

L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Felodipine is more effective than hydrochlorothiazide when added to a beta-blocker in treating elderly hypertensive patients.
January 1990, Journal of cardiovascular pharmacology,
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Antihypertensive drugs and glucose metabolism: a comparison between a diuretic and felodipine, a new calcium antagonist, when added to a beta-blocker in non-diabetic hypertensive women.
June 1994, Scottish medical journal,
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Antihypertensive efficacy of the calcium-antagonist felodipine in patients with persisting hypertension on beta-adrenoceptor blocker therapy. The Canadian Felodipine Study Group.
November 1988, British journal of clinical pharmacology,
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Antihypertensive effects and pharmacokinetics of felodipine combined with a beta-blocker and a diuretic.
January 1987, Journal of cardiovascular pharmacology,
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Comparison of nifedipine, prazosin and hydralazine added to treatment of hypertensive patients uncontrolled by thiazide diuretic plus beta-blocker.
February 1987, Postgraduate medical journal,
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
"Third drug" trial: comparative study of antihypertensive agents added to treatment when blood pressure remains uncontrolled by a beta blocker plus thiazide diuretic.
January 1984, British medical journal (Clinical research ed.),
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
[Efficacy and tolerability of felodipine and nifedipine in stable angina refractory to beta-blocker therapy].
April 1996, Giornale italiano di cardiologia,
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Antihypertensive therapy with celiprolol: a new cardioselective beta blocker.
February 1988, The American journal of cardiology,
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Effects of atenolol and propranolol when added to long-term antihypertensive diuretic therapy.
October 1979, Clinical pharmacology and therapeutics,
L Hansson, and B Dahlöf, and T Gudbrandsson, and T Hellsing, and S Kullman, and J Kuylenstierna, and J Leppert, and B Möller, and K Skogström, and A Svensson
Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: a comparison with hydralazine.
August 1975, Clinical pharmacology and therapeutics,
Copied contents to your clipboard!