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The Quin fluorescence in gamma-hexachlorocyclohexane-stimulated polymorphonuclear leukocytes is rapidly increased, which points to the increase in Ca2+in concentration during leukotriene B4 synthesis in leukocytes. An addition of EGTA and calcium antagonists (nifedipine, verapamil, diltiazem) to cell suspensions does not affect the basal level of internal Ca2+ but results in the inhibition of the gamma-hexachlorocyclohexane-induced Ca2+ increase. Two mechanisms of calcium homeostasis regulation in neutrophils are proposed. One of them, cAMP regulation, is coupled with a potent inhibiting effect of prostacyclin, an adenylate cyclase activator, on Ca2+in increase in stimulated neutrophils. The other one is the activation of protein kinase C catalyzed by 4 beta-phorbol-12 beta-myristate-13 alpha-acetate. The experimental results suggest that such an activation blocks Ca2+ influx into the cells via the closure of Ca2+ channels. The synergism of action of the above mechanisms in the regulation of calcium homeostasis in neutrophils is demonstrated.
M R Grigorian, and
S E Akopov, and
E S Gabrielian
August 1985,
Biokhimiia (Moscow, Russia),
M R Grigorian, and
S E Akopov, and
E S Gabrielian
October 1985,
Naunyn-Schmiedeberg's archives of pharmacology,
M R Grigorian, and
S E Akopov, and
E S Gabrielian
January 2000,
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica,
M R Grigorian, and
S E Akopov, and
E S Gabrielian
April 1991,
Biochemical Society transactions,
M R Grigorian, and
S E Akopov, and
E S Gabrielian
October 1986,
Biochimica et biophysica acta,
M R Grigorian, and
S E Akopov, and
E S Gabrielian
September 1992,
International journal of cancer,
M R Grigorian, and
S E Akopov, and
E S Gabrielian
July 1986,
FEBS letters,
M R Grigorian, and
S E Akopov, and
E S Gabrielian
January 1985,
Nature,
M R Grigorian, and
S E Akopov, and
E S Gabrielian
December 1991,
Lipids,
M R Grigorian, and
S E Akopov, and
E S Gabrielian
July 1998,
The American journal of pathology,
