Biomaterial Database

Feasibility and preliminary findings from a pilot study of allostatic load in adolescent-young adult childhood cancer survivors and their siblings. 2014

Sheila Judge Santacroce, and Jamie B Crandell

1The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Adolescent-young adult (AYA) childhood cancer survivors experience at least 2 types of chronic stress that can increase their risk for cardiovascular disease: the physiological stress of cancer and its treatment and the psychosocial stress inherent in the cancer experience. Their siblings can also experience ongoing cancer-related psychosocial stress. The composite biomarker allostatic load (AL) describes the cumulative impact of responses to chronic stress on interrelated organ systems and risk for stress-related diseases including cardiovascular disease. AL could be useful as a surrogate response indicator in research and care that aims to improve cardiovascular outcomes of childhood cancer. However, the measurement of AL has requirements to which AYA might not agree or adhere. This study aimed to (a) evaluate the feasibility of studying AL in AYA cancer populations and (b) briefly describe preliminary findings concerning psychological distress, cancer-related stress symptoms, health behavior and AL in AYA survivors and their siblings within the context of a small pilot study. The results support the feasibility of studying AL in AYA survivors and their siblings, and also suggest that further study of AL and risk for cardiovascular disease in both groups is indicated.

UI	MeSH Term	Description	Entries
D009369	Neoplasms	New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D010865	Pilot Projects	Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.	Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D005240	Feasibility Studies	Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.	Feasibility Study,Studies, Feasibility,Study, Feasibility
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D013315	Stress, Psychological	Stress wherein emotional factors predominate.	Cumulative Stress, Psychological,Emotional Stress,Individual Stressors,Life Stress,Psychological Cumulative Stress,Psychological Stress Experience,Psychological Stress Overload,Psychologically Stressful Conditions,Stress Experience, Psychological,Stress Measurement, Psychological,Stress Overload, Psychological,Stress Processes, Psychological,Stress, Emotional,Stressful Conditions, Psychological,Psychological Stress,Stress, Psychologic,Stressor, Psychological,Condition, Psychological Stressful,Condition, Psychologically Stressful,Conditions, Psychologically Stressful,Cumulative Stresses, Psychological,Experience, Psychological Stress,Individual Stressor,Life Stresses,Measurement, Psychological Stress,Overload, Psychological Stress,Psychologic Stress,Psychological Cumulative Stresses,Psychological Stress Experiences,Psychological Stress Measurement,Psychological Stress Measurements,Psychological Stress Overloads,Psychological Stress Processe,Psychological Stress Processes,Psychological Stresses,Psychological Stressful Condition,Psychological Stressful Conditions,Psychological Stressor,Psychological Stressors,Psychologically Stressful Condition,Stress Experiences, Psychological,Stress Processe, Psychological,Stress, Life,Stress, Psychological Cumulative,Stressful Condition, Psychological,Stressful Condition, Psychologically,Stressor, Individual
D017741	Survivors	Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.	Long-Term Survivors,Long Term Survivors,Long-Term Survivor,Survivor,Survivor, Long-Term,Survivors, Long-Term
D055815	Young Adult	A person between 19 and 24 years of age.	Adult, Young,Adults, Young,Young Adults
D035781	Siblings	Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)	Brothers,Sisters,Brother,Sibling,Sister