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The combination of irradiation and four agents of clinical interest in the treatment of cervix carcinoma (bleomycin, etoposide, cisplatin and ifosfamide) have been investigated using two human cervix carcinoma xenografts in nude mice. As a model of clinical brachytherapy regimes, radiation was administered at a continuous low dose rate of 5 cGy min-1 to a total dose of 9 or 12 Gy. No substantial enhancement in tumour growth delay over that observed for radiation alone was observed with bleomycin, etoposide or cisplatin. Ifosfamide, however, led to substantial additional growth delay, an effect which was lost when irradiation was administered at a higher dose rate of 70 cGy min-1. As dose-rates of around 5 cGy min-1 allow greater repair of radiation damage than at the higher dose-rate without significant cell cycling or repopulation, it is possible that ifosfamide may act as an inhibitor of repair processes in this model. It would be of interest to evaluate the role of ifosfamide and brachytherapy regimes in the clinical treatment of carcinoma of the cervix.
K S Tonkin, and
L R Kelland, and
G G Steel
October 1980,
British journal of cancer,
K S Tonkin, and
L R Kelland, and
G G Steel
September 1980,
Indian journal of cancer,
K S Tonkin, and
L R Kelland, and
G G Steel
January 2001,
Cancer journal (Sudbury, Mass.),
K S Tonkin, and
L R Kelland, and
G G Steel
March 1987,
Gynecologic oncology,
K S Tonkin, and
L R Kelland, and
G G Steel
June 1995,
Surgical oncology,
K S Tonkin, and
L R Kelland, and
G G Steel
January 1994,
Anticancer research,
K S Tonkin, and
L R Kelland, and
G G Steel
December 1987,
American journal of clinical oncology,
K S Tonkin, and
L R Kelland, and
G G Steel
August 1986,
International journal of radiation oncology, biology, physics,
K S Tonkin, and
L R Kelland, and
G G Steel
June 1979,
Cancer treatment reviews,
K S Tonkin, and
L R Kelland, and
G G Steel
November 1988,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
