-transparent.png){kind=logo}
Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects other than a substantive reduction in platelet reactive antibodies, such as the alteration of IgG-coated platelet destruction.
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
November 1987,
American journal of hematology,
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
June 1990,
American journal of diseases of children (1960),
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
October 1991,
American journal of hematology,
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
December 1977,
Blood,
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
October 1988,
Lancet (London, England),
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
April 1979,
European journal of pediatrics,
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
October 1983,
The Journal of pediatrics,
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
January 2004,
Journal of the American Veterinary Medical Association,
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
November 1983,
British journal of haematology,
G Barbano, and
M N Saleh, and
P G Mori, and
A F LoBuglio, and
D R Shaw
January 1987,
European journal of pediatrics,
