-transparent.png){kind=logo}
By comparing in situ negative staining of mammalian heart muscle using La(NO3)3 with conventional positive staining by uranium and lead salts, we showed that 1) the membrane area of rat cardiac gap junctions (GJs) at the intercalated disks is threefold to fourfold greater than previously thought; 2) connexon arrays of cardiac GJ are subdivided into microdomains by connexon-free aisles; 3) profiles of GJ-associated vesicles (GJAVs) of plasmalemmal origin (which are present extracellularly and sharply localized at three extracellular sites) are paired to form GJs with each other and with myocyte plasmalemma; 4) some GJAVs contain arrays of assembled connexons; and 5) myocytes contain intracytoplasmic complexes lying within cylindrical or cigar-shaped membranes and consisting of GJs and multiple vesicles apparently dissociating from these GJs.
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
August 2010,
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
March 1985,
Journal of cell science,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
July 1988,
Biochemical and biophysical research communications,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
June 2010,
Cardiology in the young,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
February 1976,
The Journal of cell biology,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
October 1991,
The Journal of biological chemistry,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
May 2020,
Circulation research,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
November 2002,
Biology of the cell,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
August 1998,
Trends in cardiovascular medicine,
L Chen, and
G E Goings, and
J Upshaw-Earley, and
E Page
January 2019,
Neuroscience,
