BIOMAT Database Logo BIOMAT Database Logo

Interaction of myelin basic protein and proteolipid protein. 1989

A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

The interaction of myelin basic protein (MBP) and proteolipid protein (PLP) was studied using a microtitre well binding assay and the ligand-blot overlay technique. The binding of iodinated PLP to MBP that was immobilized on microtitre wells was saturable and reversible. Its selectivity was investigated by the ligand-blot overlay technique. Iodinated PLP was found to bind MBP but not any other CNS myelin proteins. This interaction was not dependent on the phosphoryl moiety of MBP. Binding of PLP to histone H4 also occurred, but the amount of PLP bound per unit MBP was greater than for this histone.

UI MeSH Term Description Entries
D009185 Myelin Proteins MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure. Myelin Protein,Protein, Myelin,Proteins, Myelin
D001923 Brain Chemistry Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states. Chemistry, Brain,Brain Chemistries,Chemistries, Brain
D004676 Myelin Basic Protein An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes. Golli-MBP1 Protein,Golli-MBP2 Protein,HOG5 Protein,HOG7 Protein,MBP1 Protein,MBP2 Protein,MBP3 Protein,MBP4 Protein,Myelin Basic Protein, 17.2 kDa Isoform,Myelin Basic Protein, 18.5 kDa Isoform,Myelin Basic Protein, 20.2 kDa Isoform,Myelin Basic Protein, 21.5 kDa Isoform,Myelin Basic Protein, Isoform 1,Myelin Basic Protein, Isoform 2,Myelin Basic Protein, Isoform 3,Myelin Basic Protein, Isoform 4,Myelin Basic Protein, Isoform 5,Myelin Basic Protein, Isoform 6,Myelin Basic Protein, Isoform 7,Golli MBP1 Protein,Golli MBP2 Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018991 Myelin Proteolipid Protein A myelin protein that is the major component of the organic solvent extractable lipoprotein complexes of whole brain. It has been the subject of much study because of its unusual physical properties. It remains soluble in chloroform even after essentially all of its bound lipids have been removed. (From Siegel et al., Basic Neurochemistry, 4th ed, p122) Proteolipid Protein, Myelin,Folch-Lees Protein,Folch-PI Proteolipid Protein,Myelin PLP,Folch Lees Protein,Folch PI Proteolipid Protein,PLP, Myelin,Protein, Folch-Lees,Protein, Folch-PI Proteolipid,Protein, Myelin Proteolipid,Proteolipid Protein, Folch-PI

Related Publications

A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Structural analogies between myelin basic protein and proteolipid.
January 1984, Progress in clinical and biological research,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Mechanisms of myelin basic protein and proteolipid protein targeting in oligodendrocytes (review).
January 1994, Molecular membrane biology,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Electroblot analysis of rat myelin proteolipid protein and basic protein during development.
January 1983, Developmental neuroscience,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Expression of myelin proteolipid and basic protein mRNAs in cultured cells.
January 1986, Journal of neuroscience research,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Anti-myelin basic protein and anti-proteolipid protein specific forms of multiple sclerosis.
March 1994, Annals of neurology,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis.
November 1986, Journal of neuroimmunology,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Lipid-protein and protein-protein interactions in double recombinants of myelin proteolipid apoprotein and myelin basic protein with dimyristoylphosphatidylglycerol.
June 1991, Biochemistry,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Myelin basic protein is affected by reduced synthesis of myelin proteolipid protein in the jimpy mouse.
May 1990, The Biochemical journal,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Recent Advances in Studies on Genes for Myelin Proteins: (myelin basic protein/myelin proteolipid protein/myelin associated glycoprotein/P0 protein/P2 protein).
June 1991, Development, growth & differentiation,
A M Edwards, and N W Ross, and J B Ulmer, and P E Braun
Expression of myelin proteolipid protein and basic protein in normal and dysmyelinating mutant mice.
February 1986, Journal of neurochemistry,
Copied contents to your clipboard!