A 28-year-old female was transferred to the emergency department from her physician's office for further evaluation of tachycardia. She was being seen for a recent illness which included nausea, vomiting, diarrhea and fevers. The patient endorsed fatigue, dyspnea on exertion, and extremity edema. She had no chest pain or cough. Exam revealed a pale, fatigued, mildly ill-appearing female with bilateral lower extremity edema and diminished breath sounds on the right. Chest radiograph revealed a large right pleural effusion (Figure 1). Computed tomographic angiography of the chest was performed (Figure 2).