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Comparison of a human T-cell lymphotropic virus type I strain from cerebrospinal fluid of a Jamaican patient with tropical spastic paraparesis with a prototype human T-cell lymphotropic virus type I. 1989
P S Sarin, and
P Rodgers-Johnson, and
D K Sun, and
A H Thornton, and
O S Morgan, and
W N Gibbs, and
C Mora, and
G McKhann, and
D C Gajdusek, and
C J Gibbs
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892.
The isolation and characterization of a human T-cell lymphotropic retrovirus related to human T-cell lymphotropic virus type I (HTLV-I) from cerebrospinal fluid of a Jamaican patient with tropical spastic paraparesis is described. The virus isolate is a typical type C retrovirus as seen by electron microscopy and is related to prototype HTLV-I isolated from patients with adult T-cell leukemia but is not identical to this prototype HTLV-I as seen by restriction enzyme mapping.
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