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Structure of the yeast mitochondrial large ribosomal subunit. 2014
Alexey Amunts, and
Alan Brown, and
Xiao-Chen Bai, and
Jose L Llácer, and
Tanweer Hussain, and
Paul Emsley, and
Fei Long, and
Garib Murshudov, and
Sjors H W Scheres, and
V Ramakrishnan
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.
Mitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single-particle cryo-electron microscopy. The resolution of 3.2 angstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA. The structure reveals a new exit tunnel path and architecture, unique elements of the E site, and a putative membrane docking site.
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