Intentional interruption of the inferior vena cava with caval ligation and a Mobin-Uddin filter was once commonly used to prevent recurrent pulmonary emboli and was associated with significant mortality and morbidity, including a high incidence of post-thrombotic syndrome. Recanalization of an intentionally interrupted inferior vena cava has been rarely described in literature and is commonly considered futile. We describe two patients with post-thrombotic syndrome as a late complication of caval ligation and a thrombosed Mobin-Uddin filter, with significant and sustained improvement after endovascular recanalization.