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Two concurrent cases of haemolysis that was induced by intravenously-administered gamma-globulin are reported. Haemolysis, predominantly as a result of passively-acquired anti-A antibodies, occurred twice in one patient; anti-D antibodies also were incriminated in the first haemolytic episode. Passively-acquired anti-D antibodies that were found in the same batch of gamma-globulin contributed to the haemolytic episode in the second patient. These adverse reactions could have been prevented if a minor crossmatch procedure had been performed before the commencement of intravenous gamma-globulin therapy. It is considered important that manufacturers of intravenously-administered gamma-globulin preparations decide safe titres of these alloantibodies, and that suitable volumes be dispatched with each batch to enable a minor crossmatch procedure to be performed.
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
January 1996,
Terapevticheskii arkhiv,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
November 1993,
Nederlands tijdschrift voor geneeskunde,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
June 1995,
JAMA,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
April 1980,
Japanese journal of pharmacology,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
February 1995,
Infusionstherapie und Transfusionsmedizin,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
June 1980,
The American journal of pathology,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
February 1999,
The Journal of pediatrics,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
January 1984,
La Ricerca in clinica e in laboratorio,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
October 1953,
Nature,
M D Nicholls, and
J C Cummins, and
V J Davies, and
J K Greenwood
January 1977,
Transfusion,
