Biomaterial Database

Age-related changes in reticulin fibers and other connective tissue elements in the intima of the major intracranial arteries. 1989

K Hegedüs, and P Molnár

Department of Neurology and Psychiatry, University Medical School of Debrecen, Hungary.

The results of post mortem histological studies on the major intracranial arteries from 150 individuals, whose age varied from one day to 80 years are reported. Patients with specific vascular diseases or severe atherosclerosis were excluded. The work resulted in the following conclusions: 1) The existence of 3 types of so-called pseudoelastic fibers can be revealed by light microscopic staining procedures. All of them share some staining characteristics of true elastic fibers. Types 1 and 2 also stain to a certain extent like reticulin fibers. Type 3 pseudoelastic fibers resemble collagen fibers in some of their staining qualities. 2) At birth the internal elastic lamina (IEL) consists of true elastic fibers and type 1 pseudoelastic fibers. 3) These 2 fibers are present throughout life, though from the age of two years, type 2 pseudoelastic fibers become additional but permanent components of IEL. 4) Aging is accompanied by the appearance of collagen fibers. The relative proportion of different fibers within the IEL seems to follow a consistent sequence of changes. 5) The appearance of type 3 pseudoelastic and/or collagen fibers indicates abnormality since it is inevitably associated with loss of elasticity of the vessel wall.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D012155	Reticulin	A scleroprotein fibril consisting mostly of type III collagen. Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. They are involved in maintaining the structural integrity in a variety of organs.	Reticular Fiber,Reticular Fibers,Reticular Fibril,Reticular Fibrils,Reticulin Fiber,Reticulin Fibers,Reticulin Fibril,Reticulin Fibrils,Fiber, Reticular,Fiber, Reticulin,Fibers, Reticular,Fibers, Reticulin,Fibril, Reticular,Fibril, Reticulin,Fibrils, Reticular,Fibrils, Reticulin
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D002343	Carotid Artery, Internal	Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.	Arteries, Internal Carotid,Artery, Internal Carotid,Carotid Arteries, Internal,Internal Carotid Arteries,Internal Carotid Artery
D002536	Cerebral Arteries	The arterial blood vessels supplying the CEREBRUM.	Arteries, Cerebral,Artery, Cerebral,Cerebral Artery
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003238	Connective Tissue	Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.	Connective Tissues,Tissue, Connective,Tissues, Connective