Biomaterial Database

[Electrophoretic study of protein secretion by the prostate gland in chronic prostatitis and pathospermia]. 1989

V V Mikhaĭlichenko, and L S Pupkova, and A V Kozlov

Disk electrophoresis of prostatic secretion proteins in polyacrylamide gel has been employed in examinations of 294 normal subjects and sterile patients with oligo- and asthenospermia in the presence of and without chronic prostatitis. The electrophoregrams have been examined visually; the electrophoretic mobility (EPM) of individual fractions relative to the length of the indicator run has been determined. Analysis of the electrophoretic picture, the microscopy findings of examinations of prostatic secretion and the ejaculate, and of the blood levels of sex and gonadotrophic hormones in the patients has revealed that the progress of the inflammatory process in the prostate is associated with a drastic decrease of the concentrations of prostatic secretion proteins with a high molecular mass and an increased level of low-molecular proteins. Abnormal spermatogenesis without prostatic inflammation is linked with a different pattern of prostatic protein levels. A specific electrophoretic picture is characteristic of congestive prostatitis, this helping to differentiate this condition from prostatic inflammations. High informative value and good reproducibility of disk electrophoresis of the prostatic secretion proteins recommend this method for wide use in practical andrology.

UI	MeSH Term	Description	Entries
D007248	Infertility, Male	The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.	Sterility, Male,Sub-Fertility, Male,Subfertility, Male,Male Infertility,Male Sterility,Male Sub-Fertility,Male Subfertility,Sub Fertility, Male
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011472	Prostatitis	Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.	Acute Bacterial Prostatitis,Asymptomatic Inflammatory Prostatitis,Chronic Bacterial Prostatitis,Chronic Prostatitis with Chronic Pelvic Pain Syndrome,Acute Bacterial Prostatitides,Asymptomatic Inflammatory Prostatitides,Bacterial Prostatitides, Acute,Bacterial Prostatitides, Chronic,Bacterial Prostatitis, Acute,Bacterial Prostatitis, Chronic,Chronic Bacterial Prostatitides,Inflammatory Prostatitis, Asymptomatic,Prostatitides,Prostatitides, Chronic Bacterial
D002352	Carrier Proteins	Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes.	Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D004589	Electrophoresis, Disc	Electrophoresis in which discontinuities in both the voltage and pH gradients are introduced by using buffers of different composition and pH in the different parts of the gel column. The term 'disc' was originally used as an abbreviation for 'discontinuous' referring to the buffers employed, and does not have anything to do with the shape of the separated zones.	Electrophoresis, Disk,Disc Electrophoresis,Disk Electrophoresis
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D029584	Prostatic Secretory Proteins	Proteins secreted by the prostate gland. The major secretory proteins from the human prostate gland include PROSTATE-SPECIFIC ANTIGEN, prostate-specific acid phosphatase, prostate-specific membrane antigen, and prostate-specific protein-94.	Proteins, Prostatic Secretory,Secretory Proteins, Prostatic