BIOMAT Database Logo BIOMAT Database Logo

A specific quisqualate agonist inhibits kainate responses induced in Xenopus oocytes injected with rat brain RNA. 1989

F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
CNRS Centre de Recherche de Biochimie Macromoléculaire, INSERM U 249, Montpellier, France.

Electrophysiological recording was used to study non-N-methyl-D-aspartate (NMDA) excitatory amino acid (EAA) receptors after injection of rat brain ribonucleic acid (RNA) in Xenopus laevis oocytes. Quisqualate (QA) induced two types of responses, a smooth one and an oscillatory one. These responses are probably mediated by the ionotropic (QAi, a cationic channel) and the metabotropic (QAp, a newly discovered receptor coupled to phospholipase C) QA receptors respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) only induced a smooth inward current suggesting that it acts only on QAi. Kainate (KA) also induced a smooth inward current, the maximal KA response being 10-fold higher than the maximal AMPA. AMPA inhibited the KA response in a dose-dependent and competitive manner. Amongst various complex hypotheses the simplest to explain these results would be that KA and AMPA both activate the same receptor-channel complex, AMPA inducing a smaller response than KA.

UI MeSH Term Description Entries
D007051 Ibotenic Acid A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist. Acid, Ibotenic
D007608 Kainic Acid (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose. Digenic Acid,Kainate,Acid, Digenic,Acid, Kainic
D007700 Kinetics The rate dynamics in chemical or physical systems.
D009865 Oocytes Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM). Ovocytes,Oocyte,Ovocyte
D010069 Oxadiazoles Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms. Oxadiazole
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D003292 Convulsants Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools. Convulsant,Convulsant Effect,Convulsant Effects,Effect, Convulsant,Effects, Convulsant
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012313 RNA A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) RNA, Non-Polyadenylated,Ribonucleic Acid,Gene Products, RNA,Non-Polyadenylated RNA,Acid, Ribonucleic,Non Polyadenylated RNA,RNA Gene Products,RNA, Non Polyadenylated

Related Publications

F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Protein kinase C modulates neurotransmitter responses in Xenopus oocytes injected with rat brain RNA.
May 1989, Brain research. Molecular brain research,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes.
April 1984, Proceedings of the Royal Society of London. Series B, Biological sciences,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Pharmacological properties of quisqualate- and kainate-preferring glutamate receptors induced in Xenopus oocytes by rat and chick brain mRNA.
November 1989, Neuroscience research,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Tetrabutylammonium induces a voltage-dependent block of kainate current in Xenopus oocytes injected with rat brain mRNA.
August 1990, Canadian journal of physiology and pharmacology,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Inhibitory effects of antidepressants on NMDA-induced currents in Xenopus oocytes injected with rat brain RNA.
January 1995, Neurochemistry international,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Properties of the kainate channel in rat brain mRNA injected Xenopus oocytes: ionic selectivity and blockage.
January 1988, Molecular and cellular biochemistry,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Tryptophan inhibits the [3H]glutamate uptake into Xenopus oocytes injected with rat brain mRNA.
August 1992, Japanese journal of pharmacology,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Specific quisqualate receptor ligand blocks both kainate and quisqualate responses.
January 1990, Advances in experimental medicine and biology,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Spermine and philanthotoxin potentiate excitatory amino acid responses of Xenopus oocytes injected with rat and chick brain RNA.
June 1990, Neuroscience letters,
F A Rassendren, and P Lory, and J P Pin, and J Bockaert, and J Nargeot
Guanine nucleotides, including GMP, antagonize kainate responses in Xenopus oocytes injected with chick cerebellar membranes.
May 1999, Journal of neurochemistry,
Copied contents to your clipboard!