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The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis. 2014
Andreia Henriques, and
Regina Arantes-Rodrigues, and
Ana I Faustino-Rocha, and
Catarina I Teixeira-Guedes, and
Jacinta Pinho-Oliveira, and
Daniela Talhada, and
José H Teixeira, and
Andreia Andrade, and
Bruno Colaço, and
Maria N Paiva-Cardoso, and
Maria J Pires, and
Ana Mvd Ferreira, and
Fernando M Nunes, and
Paula A Oliveira
Department of Veterinary Sciences, ECAV, University of Trás-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal.
OBJECTIVE Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carcinogenesis in male and female ICR mice. METHODS The GT characterization was performed using spectrophotometric methods. Urinary bladder lesions were induced using N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) by gavage during 10 weeks and whole GT (0.5%) was provided ad libitum during 20 weeks. RESULTS Animals from groups BBN+GT and BBN only developed preneoplastic lesions. CONCLUSIONS We did not observe any effects by GT infusion administration on urinary bladder cancer development.
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