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Epitopes of strain A22 Iraq 24/64 of foot-and-mouth disease virus have been mapped with monoclonal antibodies (MAbs). Three methods were used: (i) an indirect ELISA using an overlapping set of peptides, (ii) production of neutralization escape variants against each MAb and (iii) sequencing of neutralization escape variants. The study has shown that the virus has at least three overlapping liner neutralizing epitopes within a major antigenic site on VP1. The presence of a second, conformational site was demonstrated but its position on the virus particle was not located. Synthetic peptides with sequences representing the major site elicit antibodies which have similar broad cross-neutralizing activity to polyclonal serum or neutralizing MAbs produced with the virus against a range of field isolates.
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
September 1984,
The Journal of general virology,
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
January 2022,
Frontiers in veterinary science,
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
January 1989,
Viral immunology,
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
June 1989,
Journal of virology,
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
July 1986,
Immunology,
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
January 1993,
Viral immunology,
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
February 2011,
Journal of microbiology (Seoul, Korea),
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
October 1986,
Virus research,
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
November 2012,
Journal of virology,
C Bolwell, and
B E Clarke, and
N R Parry, and
E J Ouldridge, and
F Brown, and
D J Rowlands
July 1993,
Immunology,
