-transparent.png){kind=logo}
New cholecystokinin (CCK) receptor antagonist, CR 1409 (lorglumide), was evaluated for anti-CCK activity on pancreatic exocrine secretion in anesthetized rats in vivo, compared with proglumide. Both CR 1409 in a dose range of 0.04-25 mg/kg-hr and proglumide in a dose range of 30-600 mg/kg-hr given intravenously, showed significant inhibitory effect on pancreatic secretion in terms of juice volume and amylase output stimulated by intravenous CCK-8 (0.06 micrograms/kg-hr), in a dose-related manner. CR 1409 is about 1000 times more potent than proglumide, based on ED 50. Furthermore, intravenous administration of either CR 1409 (5 mg/kg-hr) or proglumide (600 mg/kg-hr) resulted in significant suppression on pancreatic secretion stimulated by intraduodenal casein in a dose of 400 mg/hr. Thus, very potent CCK receptor antagonist, CR 1409, inhibited pancreatic exocrine secretion stimulated by not only exogenous CCK, but also intraduodenal casein in rats.
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
June 1988,
The Tohoku journal of experimental medicine,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
January 1986,
Peptides,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
April 1992,
International journal of pancreatology : official journal of the International Association of Pancreatology,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
October 1989,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
January 1990,
Pancreas,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
October 1988,
Regulatory peptides,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
January 1989,
The Japanese journal of physiology,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
June 1994,
Digestive diseases and sciences,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
March 1994,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K Shiratori, and
S Watanabe, and
K Shimizu, and
Y Moriyoshi, and
J H Chang, and
T Takeuchi
April 1995,
Pancreas,
