-transparent.png){kind=logo}
Although most investigators agree that the CD4- CD8- CD3- thymocyte subset represents the most immature intrathymic T cell capable of repopulating the thymus in vivo, little is known of the earliest stages of human T-cell development. Using mAbs to hematopoietic and T-cell lineage molecules in quantitative immunofluorescence studies, new insight has been gained regarding the phenotype of human T-cell precursors before and after colonization of human thymic rudiment. In this article, Barton Haynes and colleagues discuss the sequential expression of CD7, CD4, CD8, CD3, CD2, CD1, CD45, TCR gamma delta and TCR alpha beta, and propose a model defining the stages of T-cell precursors during fetal ontogeny.
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
August 1990,
Hematology/oncology clinics of North America,
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
November 2017,
Leukemia,
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
September 1988,
The Journal of experimental medicine,
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
September 1977,
The Journal of experimental medicine,
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
April 1994,
Current opinion in immunology,
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
December 1993,
Blood,
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
July 1986,
Journal of immunology (Baltimore, Md. : 1950),
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
August 1990,
Clinical immunology and immunopathology,
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
December 1984,
Immunological reviews,
B F Haynes, and
S M Denning, and
K H Singer, and
J Kurtzberg
January 1987,
Experimental and clinical immunogenetics,
