-transparent.png){kind=logo}
The effects of transforming growth factor-beta (TGF-beta) on the blast progenitors from nine acute myeloblastic leukemia patients were studied in methylcellulose and suspension cultures. Leukemic blast progenitors undergo terminal divisions with a limited differentiation in methylcellulose culture, making blast colonies. Blast progenitors can renew themselves. The self-renewal can be reflected by secondary colony formation after replating primary blast colonies in fresh methylcellulose media and by the exponential growth of clonogenic cells in suspension culture. TGF-beta suppressed primary and secondary colony-formation in methylcellulose culture. Furthermore, TGF-beta suppressed the recovery of clonogenic cells in suspension. The results indicate that TGF-beta is effective in inhibiting not only terminal divisions but also self-renewal of leukemic blast progenitors.
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
July 1988,
Blood,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
December 1992,
Japanese journal of cancer research : Gann,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
December 1995,
Experimental hematology,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
October 1995,
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
January 1986,
Leukemia research,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
February 1987,
Blood,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
September 1978,
Blood,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
May 1988,
Cancer research,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
October 1992,
Proceedings of the National Academy of Sciences of the United States of America,
N Nara, and
S Tohda, and
K Nagata, and
T Suzuki, and
Y Yamashita
March 1998,
The international journal of biochemistry & cell biology,
