Influenza H1N1pdm-specific maternal antibodies offer limited protection against wild-type virus replication and influence influenza vaccination in ferrets. 2014

Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin

OBJECTIVE The objective was to study passively acquired influenza H1N1 pandemic (H1N1pdm) maternal antibody kinetics and its impact on subsequent influenza infection and vaccination in ferrets during an outbreak of the H1N1pdm. METHODS Infectivity of the H1N1pdm in the respiratory tract of ferrets was compared with the previous seasonal A/South Dakota/6/2007 (SD07, H1N1). Influenza-specific antibodies were quantitated and antibody-mediated protection against the homologous and heterologous H1N1 virus challenge infection was determined. RESULTS H1N1pdm virus was approximately 10 times more infectious than SD07 in ferrets, replicated to higher viral titers in the upper respiratory tract and shed for a longer duration. Influenza-specific antibodies after natural infection persisted much longer in the circulation than passively acquired maternal antibodies. The protection conferred by the maternal antibodies was limited to the homologous virus strain and was ineffective against SD07 and H3N2 virus. Serum antibodies from maternal transmission or passive transfer interfered with homologous vaccine strain-mediated antibody responses in the ferret. A booster immunization was required to elicit a high level of antibody. CONCLUSIONS The findings support the rationale for a prime and boost immunization strategy in young children in whom maternal antibodies are present.

UI MeSH Term Description Entries
D007112 Immunity, Maternally-Acquired Resistance to a disease-causing agent induced by the introduction of maternal immunity into the fetus by transplacental transfer or into the neonate through colostrum and milk. Fetal Immunity, Maternally-Acquired,Maternally-Acquired Immunity,Neonatal Immunity, Maternally-Acquired,Immunity, Maternally Acquired,Fetal Immunities, Maternally-Acquired,Fetal Immunity, Maternally Acquired,Immunity, Maternally-Acquired Fetal,Immunity, Maternally-Acquired Neonatal,Maternally Acquired Immunities,Maternally Acquired Immunity,Maternally-Acquired Fetal Immunities,Maternally-Acquired Fetal Immunity,Maternally-Acquired Immunities,Maternally-Acquired Neonatal Immunities,Maternally-Acquired Neonatal Immunity,Neonatal Immunities, Maternally-Acquired,Neonatal Immunity, Maternally Acquired
D007252 Influenza Vaccines Vaccines used to prevent infection by viruses in the family ORTHOMYXOVIRIDAE. It includes both killed and attenuated vaccines. The composition of the vaccines is changed each year in response to antigenic shifts and changes in prevalence of influenza virus strains. The flu vaccines may be mono- or multi-valent, which contains one or more ALPHAINFLUENZAVIRUS and BETAINFLUENZAVIRUS strains. Flu Vaccine,Influenzavirus Vaccine,Monovalent Influenza Vaccine,Universal Flu Vaccine,Universal Influenza Vaccine,Flu Vaccines,High-Dose Trivalent Influenza Vaccine,Influenza Vaccine,Influenza Virus Vaccine,Influenza Virus Vaccines,Influenzavirus Vaccines,Intranasal Live-Attenuated Influenza Vaccine,LAIV Vaccine,Monovalent Influenza Vaccines,Quadrivalent Influenza Vaccine,Trivalent Influenza Vaccine,Trivalent Live Attenuated Influenza Vaccine,Universal Flu Vaccines,Universal Influenza Vaccines,Flu Vaccine, Universal,High Dose Trivalent Influenza Vaccine,Influenza Vaccine, Monovalent,Influenza Vaccine, Quadrivalent,Influenza Vaccine, Trivalent,Influenza Vaccine, Universal,Intranasal Live Attenuated Influenza Vaccine,Vaccine, Flu,Vaccine, Influenza,Vaccine, Influenza Virus,Vaccine, Influenzavirus,Vaccine, LAIV,Vaccine, Monovalent Influenza,Vaccine, Quadrivalent Influenza,Vaccine, Trivalent Influenza,Virus Vaccine, Influenza
D009976 Orthomyxoviridae Infections Virus diseases caused by the ORTHOMYXOVIRIDAE. Orthomyxovirus Infections,Infections, Orthomyxoviridae,Infections, Orthomyxovirus,Swine Influenza,Infection, Orthomyxoviridae,Infection, Orthomyxovirus,Influenza, Swine,Orthomyxoviridae Infection,Orthomyxovirus Infection
D005289 Ferrets Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE. Domestic Polecat,Domestic Polecats,European Polecat,European Polecats,Ferret,Mustela putorius,Mustela putorius furo,Polecat, Domestic,Polecat, European,Polecats, Domestic,Polecats, European
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D014611 Vaccination Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis. Immunization, Active,Active Immunization,Active Immunizations,Immunizations, Active,Vaccinations
D014779 Virus Replication The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle. Viral Replication,Replication, Viral,Replication, Virus,Replications, Viral,Replications, Virus,Viral Replications,Virus Replications
D017201 Virus Shedding The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract (important in INFECTIOUS DISEASE TRANSMISSION, VERTICAL), and intestinal tract. Viral Shedding,Shedding, Viral,Shedding, Virus
D053118 Influenza A Virus, H1N1 Subtype A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918 and 2009 H1N1 pandemic. H1N1 Influenza Virus,H1N1 Virus,H1N1 subtype,H1N1v Viruses,Influenza A (H1N1)pdm09,Influenza A (H1N1)pdm09 Virus,Influenza A H1N1, Variant Virus,Swine-Origin Influenza A H1N1 Virus,H1N1 Influenza Viruses,H1N1 Viruses,H1N1 subtypes,H1N1v Virus,Influenza Virus, H1N1,Swine Origin Influenza A H1N1 Virus,Virus, H1N1,Virus, H1N1 Influenza,Virus, H1N1v,subtype, H1N1

Related Publications

Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
January 2019, NPJ vaccines,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
July 1991, Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
January 2016, PloS one,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
July 1984, Immunology,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
April 2011, Vaccine,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
October 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
June 2014, Journal of virology,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
October 1987, The Journal of general virology,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
December 2010, Avian diseases,
Amorsolo L Suguitan, and James R Zengel, and Scott Jacobson, and Stephanie Gee, and Janet Cetz, and Paulyn Cha, and Zhongying Chen, and Rosemary Broome, and Hong Jin
October 2010, Journal of virology,
Copied contents to your clipboard!