Valve-sparing aortic root replacement†. 2015

David R Koolbergen, and Johan S J Manshanden, and Berto J Bouma, and Nico A Blom, and Barbara J M Mulder, and Bas A J M de Mol, and Mark G Hazekamp
Department of Cardiothoracic Surgery, Academic Medical Center, Amsterdam, Netherlands Department of Paediatric Cardiology, Leiden University Medical Center, Leiden, Netherlands d.r.koolbergen@amc.nl.

OBJECTIVE To evaluate our results of valve-sparing aortic root replacement and associated (multiple) valve repair. METHODS From September 2003 to September 2013, 97 patients had valve-sparing aortic root replacement procedures. Patient records and preoperative, postoperative and recent echocardiograms were reviewed. Median age was 40.3 (range: 13.4-68.6) years and 67 (69.1%) were male. Seven (7.2%) patients were younger than 18 years, the youngest being 13.4 years. Fifty-four (55.7%) had Marfan syndrome, 2 (2.1%) other fibrous tissue diseases, 15 (15.5%) bicuspid aortic valve and 3 (3.1%) had earlier Fallot repair. The reimplantation technique was used in all, with a straight vascular prosthesis in 11 (26-34 mm) and the Valsalva prosthesis in 86 (26-32 mm). Concomitant aortic valve repair was performed in 43 (44.3%), mitral valve repair in 10 (10.3%), tricuspid valve repair in 5 (5.2%) and aortic arch replacement in 3 (3.1%). RESULTS Mean follow-up was 4.2 ± 2.4 years. Follow-up was complete in all. One 14-year old patient died 1.3 years post-surgery presumably of ventricular arrhythmia. One patient underwent reoperation for aneurysm of the proximal right coronary artery after 4.9 years and 4 patients required aortic valve replacement, 3 of which because of endocarditis after 0.1, 0.8 and 1.3 years and 1 because of cusp prolapse after 3.8 years. No thrombo-embolic complications occurred. Mortality, root reoperation and aortic regurgitation were absent in 88.0 ± 0.5% at 5-year follow-up. CONCLUSIONS Results of valve-sparing root replacement are good, even in association with a high incidence of concomitant valve repair. Valve-sparing aortic root replacement can be performed at a very young age as long as an adult size prosthesis can be implanted.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001021 Aortic Valve The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle. Aortic Valves,Valve, Aortic,Valves, Aortic
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D053208 Kaplan-Meier Estimate A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995) Kaplan-Meier Survival Curve,Kaplan-Meier Analysis,Kaplan-Meier Survival Curves,Kaplan-Meier Test,Product-Limit Method,Analysis, Kaplan-Meier,Curve, Kaplan-Meier Survival,Curves, Kaplan-Meier Survival,Estimate, Kaplan-Meier,Kaplan Meier Analysis,Kaplan Meier Survival Curve,Kaplan Meier Survival Curves,Kaplan Meier Test,Method, Product-Limit,Methods, Product-Limit,Product Limit Method,Product-Limit Methods,Survival Curve, Kaplan-Meier,Survival Curves, Kaplan-Meier,Test, Kaplan-Meier
D058385 Cardiac Valve Annuloplasty A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annuli of HEART VALVES. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs. Annular Reduction, Cardiac Valve,Annular Repair, Cardiac Valve,Annulus Reduction, Cardiac Valve,Annulus Repair, Cardiac Valve,Cardiac Valve Annular Reduction,Cardiac Valve Annular Repair,Cardiac Valve Annulus Reduction,Cardiac Valve Annulus Repair,Cardiac Valve Annulus Shortening,Heart Valve Annular Repair,Heart Valve Annuloplasty,Heart Valve Annulus Repair,Valvular Annuloplasty,Annuloplasties, Cardiac Valve,Annuloplasties, Heart Valve,Annuloplasties, Valvular,Annuloplasty, Cardiac Valve,Annuloplasty, Heart Valve,Annuloplasty, Valvular,Cardiac Valve Annuloplasties,Heart Valve Annuloplasties,Valve Annuloplasties, Cardiac,Valve Annuloplasties, Heart,Valve Annuloplasty, Cardiac,Valve Annuloplasty, Heart,Valvular Annuloplasties
D059351 Organ Sparing Treatments Techniques, procedures, and therapies carried out on diseased organs in such a way to avoid complete removal of the organ and preserve the remaining organ function. Organ Sparing Treatment,Sparing Treatment, Organ,Sparing Treatments, Organ,Treatment, Organ Sparing,Treatments, Organ Sparing

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