-transparent.png){kind=logo}
At the Center for Experimental Plants and Animals, Hokkaido University, two inbred strains, Long Evans Cinnamon (LEC) and Long Evans Agouti (LEA), which were selected for coat colour, were isolated from a closed colony of Long Evans rats. While the two inbred strains were maintained by sibmating, only LEC rats, over 24-generation, spontaneously developed acute hepatitis with sudden appearance of systemic jaundice at around four months after birth. The frequency of acute hepatitis was 80 to 90% and the disease in nearly 80% of these rats were progressive and they died within two weeks after onset, with their clinical course and histopathological findings similar to those of human fulminant hepatitis. LEC rats with spontaneous hepatitis had strong-conversion of urine-bilirubin, ultimate increase of blood-bilirubin and abnormal increase of serum-transaminases (GOT, GPT; GOT greater than GPT). Histopathological findings of the livers in the rats with acute hepatitis showed spotty necrosis and abnormal hepatocytes containing giant bizarre nuclei and in the rats with fulminant-type hepatitis showed central or coagulated necrosis and marked infiltration of inflammatory cells. Serum levels of albumin in LEC rats before being affected by hepatitis were low compared with those of LEA rats and especially characteristic fact was that cellulose-acetate electrophoresis could not reveal gamma-globulin fraction in LEC rats of 6-week and 12-week old, which will be a clue to analyze the etiology of hepatitis in LEC rats.
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
June 1993,
The Journal of veterinary medical science,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
May 1999,
Journal of comparative pathology,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
January 1999,
Anticancer research,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
December 1993,
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
November 1993,
Investigative radiology,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
April 1998,
European journal of clinical investigation,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
April 1996,
Toxicology,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
July 1993,
Research communications in chemical pathology and pharmacology,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
June 1994,
Japanese journal of cancer research : Gann,
T Namieno, and
N Takeichi, and
K Dempo, and
M Mori, and
J Uchino, and
M Sasaki, and
H Kobayashi
November 1999,
Archives of toxicology,
