In a clinical study altogether 449 machine donor plasmapheresis for collection of platelet poor fresh plasma were carried out using the new developed Haemonetics-Ultralite-Plasma-Collection-System. The average time of donation for 600 g of plasma amounted to 36 min. In comparison to other automated plasmapheresis-systems an effective plasma flow is recorded for the Ultralite-machine. All plasmapheresis procedures were well tolerated by the donors. The collected plasma is equivalent to the requirements for fresh frozen plasma. Complications due to the device or donors are small with 2.9% of the performed procedures.