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Monoclonal antibodies have been derived against a variety of antigens on human leukocytes. We describe a complement-fixing, IgG2a, murine monoclonal antibody that was derived against ARH-77, a human plasma cell line. In a Western blot of a lysate of ARH-77, anti-ARH-77 recognized a 155 kD protein. On normal B cells, the antibody co-capped with surface immunoglobulin. Analysis of blood and lymph nodes indicated that the determinant recognized by the antibody is expressed by most B cells, T cells, monocytes, and lymphomas with surface immunoglobulin. The determinant was not present on granulocytes, platelets, mantle zone lymphocytes, or serum immunoglobulin. We conclude that anti-ARH-77 is a cytotoxic monoclonal antibody that recognizes a determinant shared by human mononuclear leukocytes. The determinant may be an exposed part of a membrane anchor or bridging protein associated with receptors on mononuclear cells.
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
April 1981,
Journal of immunology (Baltimore, Md. : 1950),
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
July 1982,
Microbiology and immunology,
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
January 1982,
Microbiology and immunology,
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
January 1992,
Hematologic pathology,
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
May 1986,
Investigative ophthalmology & visual science,
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
January 1988,
Annales de recherches veterinaires. Annals of veterinary research,
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
December 1987,
Bone marrow transplantation,
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
February 2008,
Hybridoma (2005),
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
November 1990,
The Journal of experimental medicine,
M K Samoszuk, and
F Gidanian, and
M Lo-Hsueh, and
C Rietveld
October 1990,
Hybridoma,
