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It is well established that a large dose of atracurium (more than twice ED95) produces significant release of histamine in the blood accompanying hypotension but recovery to control level within a few minutes after the administration of atracurium. We speculated that laudanosine, a metabolite of atracurium may play an important role in preventing this cardiovascular disaster due to histamine release. From this concept, we investigated the effect of laudanosine on the release of epinephrine and norepinephrine in dogs, anesthetized with halothane, nitrous oxide and oxygen. Two different doses of laudanosine (1 microgram.kg-1 and 10 micrograms.kg-1) were selected and serum catecholamine levels were measured with HPLC in six dogs. Intravenous injection of 1.0 microgram.kg-1 laudanosine increased NE level from 0.11 +/- 0.03ng.ml-1 to 0.13 +/- 0.04ng.ml-1 at 3 minutes after the injection. Blood pressure, heart rate, pulmonary arterial pressure, pulmonary wedge pressure and central venous pressure did not change significantly. The intravenous injection of 10 micrograms.kg-1 laudanosine increased NE level from 0.09 +/- 0.02ng.ml-1 to 0.14 +/- 0.02ng.ml-1 at 1 minutes after the injection, but there was no remarkable cardiovascular effect. From this study we conclude that the intravenous injection of laudanosine increased serum NE level, but there was no significant hemodynamic change in the dogs.
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
July 1986,
Anesthesiology,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
June 1989,
British journal of anaesthesia,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
April 1999,
The American journal of physiology,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
April 1969,
Metabolism: clinical and experimental,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
February 1969,
Journal of applied physiology,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
January 1969,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
April 2004,
European journal of pharmacology,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
November 1985,
British journal of anaesthesia,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
April 1985,
Clinical pharmacology and therapeutics,
K Fukushima, and
K Watanabe, and
T Kikuya, and
T Satoh, and
K Uchida, and
H Nagashima
January 1986,
The American journal of physiology,
