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The effect of atrial natriuretic factor (ANF) 99-126 3 or 10 pmol/kg/min on increase in plasma renin activity (PRA) stimulated by a 30-min infusion of prostaglandin E2 (PGE2) 80 ng/kg/min was studied in healthy salt-replete male volunteers. PGE2 increased PRA to approximately 230% of basal levels (p less than 0.001). Concomitant infusion of ANF 3 pmol/kg/min significantly attenuated this rise in PRA to approximately 130% of baseline values (p = 0.02, n = 10). A quantitatively similar effect was observed with ANF 10 pmol/kg/min (n = 5). We suggest, in light of previous findings, that this inhibitory effect of ANF probably represents a nonspecific action rather than a specific effect of ANF on PGE2-mediated increases in PRA.
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
January 1989,
Hypertension (Dallas, Tex. : 1979),
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
February 1988,
Hypertension (Dallas, Tex. : 1979),
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
June 1988,
Journal of the American College of Cardiology,
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
April 1988,
The American journal of physiology,
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
June 1990,
Scandinavian journal of clinical and laboratory investigation,
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
January 1985,
Annales francaises d'anesthesie et de reanimation,
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
February 1982,
The Journal of laboratory and clinical medicine,
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
January 1992,
Parasitology research,
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
January 1985,
Annales francaises d'anesthesie et de reanimation,
J McMurray, and
L McFarlane, and
W Coutie, and
D Balfour, and
A Struthers
August 1992,
Acta physiologica Scandinavica,
