We here in describe a case of hypereosinophilic syndrome (HES) with acute cerebral infarction in a watershed distribution with lesions of the carotid artery but no damage to the endocardium or myocardium. A 62-year-old Chinese man complained of left-sided hemiparesis. Brain MR showed multiple areas of acute ischemia. The eosinophil count was 4.84 × 10(9)/L, or 41.7 % of all white blood cells. Doppler ultrasound showed multiple medium-high echo plaques in the bilateral carotid bifurcation with reduction in diameter of 10-15 %. Transthoracic echocardiography was normal. A short course of glucocorticoids and aspirin were administered to the patient, and he was discharged with significant improvement of his neurological symptoms and eosinophil count. The patient refused to take prednisone thereafter; however, 6 months later, his eosinophil count was 1.57 × 10(9)/L, or 15.3 % of all white blood cells. Transthoracic echocardiography continued to be normal, but vascular ultrasound demonstrated many bilateral carotid low-medium echo plaques. This case describes a patient HES with acute cerebral infarction in a watershed distribution with lesions of the carotid artery but no cardiac damage. HES should be considered to be a cause of multiple cerebral infarctions.