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XK81A1 is a type I epidermal keratin gene expressed in early developmental stages of Xenopus (Jonas et al. 1985). Fusion of the keratin promoter (-5900 to +26) to a human beta globin gene led to fully epidermis-specific accumulation of human globin mRNA and protein when this DNA was injected into fertilized eggs. Further localization of regulatory sequences was accomplished by injecting marked, 5'-deleted keratin gene DNA into fertilized eggs and evaluating tissue specificity of expression. All 5' flanking DNA upstream from -487 could be removed without interfering with keratin gene expression or regulation. These results suggest that the primary mode of regulation of epidermis-specific keratin gene expression is at the level of transcription, and that sequence elements in the 5' flanking region of the keratin gene, between -487 and +26, are responsible for this regulation.
E A Jonas, and
A M Snape, and
T D Sargent
December 2002,
Developmental dynamics : an official publication of the American Association of Anatomists,
E A Jonas, and
A M Snape, and
T D Sargent
August 1985,
Proceedings of the National Academy of Sciences of the United States of America,
E A Jonas, and
A M Snape, and
T D Sargent
September 1988,
Nucleic acids research,
E A Jonas, and
A M Snape, and
T D Sargent
February 2004,
Development (Cambridge, England),
E A Jonas, and
A M Snape, and
T D Sargent
March 1992,
Differentiation; research in biological diversity,
E A Jonas, and
A M Snape, and
T D Sargent
June 1982,
The Journal of cell biology,
E A Jonas, and
A M Snape, and
T D Sargent
April 1992,
Epithelial cell biology,
E A Jonas, and
A M Snape, and
T D Sargent
April 1991,
Development, growth & differentiation,
E A Jonas, and
A M Snape, and
T D Sargent
May 1992,
Developmental biology,
E A Jonas, and
A M Snape, and
T D Sargent
May 1985,
The EMBO journal,
