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We developed a specific and sensitive bioassay for measuring plasma cholecystokinin (CCK) in human and investigated CCK response after a test meal in patients with chronic pancreatitis. Treatment with cycloheximide increased the sensitivity and responsiveness of isolated rat pancreatic acini to CCK-octapeptide (CCK-8) and thus plasma levels of CCK-8 as low was 0.17 pM were detectable. Fasting plasma CCK levels in normal subjects as CCK-8 equivalents were 0.75 +/- 0.25 pM and rose to a peak of 6.2 +/- 0.68 pM at 45 min after a test meal consisting of 400 ml milk and 2 boiled eggs. Basal and stimulated plasma levels of CCK-8 in patients with non-calcified chronic pancreatitis were significantly higher than those in normal subjects. In contrast, postprandial responses of plasma CCK-8 in patients with calcified chronic pancreatitis was significantly low compared to those in control subjects, although basal plasma levels were not significantly different from those in controls.
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
January 1985,
Digestion,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
January 1986,
Pancreas,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
August 1989,
Zeitschrift fur Gastroenterologie,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
January 2000,
Hepato-gastroenterology,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
December 1986,
The American journal of gastroenterology,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
December 1991,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
December 1983,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
December 1984,
Digestive diseases and sciences,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
December 1985,
The American journal of gastroenterology,
M Koide, and
Y Okabayashi, and
H Hasegawa, and
S Tani, and
T Fujisawa, and
T Nakamura, and
M Fujii, and
M Otsuki
June 1979,
Cancer,
