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Multicentric prevalence study of anti P ribosomal autoantibodies in juvenile onset systemic lupus erythematosus compared with adult onset systemic lupus erythematosus. 2015
Cecilia N Pisoni, and
Sebastián Andrés Muñoz, and
Carolina Carrizo, and
Micaela Cosatti, and
Analía Álvarez, and
Diana Dubinsky, and
Eleonora Bresan, and
Ricardo Russo, and
Ezequiel Borgia, and
Mercedes García, and
Pierina Sansinanea, and
María Cristina Basta, and
Maria Agustina D'Amico, and
Juan Carlos Barreira, and
Eliana Lancioni, and
Enrique Soriano, and
Carmen de Cunto, and
Ana Beron, and
Alicia Eimon
Sección Reumatología, Departamento de Medicina, Centro de Educación Médica y de Investigaciones Clínicas Norberto Quirno (CEMIC), Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: ceciliapisoni@gmail.com.
OBJECTIVE To investigate the prevalence and associations with clinical manifestations of anti- P ribosomal antibodies in patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE). METHODS Clinical and serological data of 30 patients with juvenile-onset SLE (age at onset younger than 16 years old) were compared with data of 92 patients with adult-onset SLE. Symptoms occurring during the entire disease course were considered. Anti- P ribosomal antibodies were tested by ELISA. RESULTS Anti- P ribosomal antibodies were found significantly more often in pediatric-onset SLE patients (26.7% vs. 6.5%; OR=5.21 [CI95%=1.6-16.5], p=0.003). Alopecia (OR=10.11, CI 95%=1.25-97) and skin rash (non discoid) (OR=4.1, CI 95%=1.25-13.89) were significantly associated with anti- P ribosomal antibodies. CONCLUSIONS Anti-ribosomal P antibodies are more often found in patients with juvenile SLE. Alopecia and skin rash were the only clinical manifestations associated to anti-ribosomal P antibodies.
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