Grafting parastomal wounds remains a challenging procedure because of frequent contamination, difficulty isolating the grafted area from the stoma, and an unfavorable environment for skin graft take. The use of negative-pressure dressings has been shown to improve skin graft take by removing excess fluid between the graft and the wound bed, thereby accelerating engraftment. The benefits of negative-pressure dressing around a stoma, however, may be hindered by vacuuming stool into the dressed area. This article reviews a novel approach used for the isolation of a stoma from the parastomal wound area to increase skin graft take in an 82-year-old woman.