Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity. 2014

Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
Department of Kinesiology, University of Georgia, 330 River Road, Athens, GA 30602-6554, USA. Electronic address: dmon@uga.edu.

Rats selectively bred for high- and low-capacity for running on a treadmill (HCR; LCR) also differ in wheel-running behavior, but whether wheel-running can be explained by intrinsic or adaptive brain mechanisms is not as yet understood. It is established that motivation of locomotory behavior is driven by dopaminergic transmission in mesolimbic and mesostriatal systems. However, whether voluntary wheel running is associated with enkephalinergic activity in the ventral striatum is not known. METHODS 40 male (20 HCR and 20 LCR) and 40 female (20 HCR and 20 LCR) rats were randomly assigned to 3 weeks of activity wheel exposure or sedentary conditions without wheel access. After 3 weeks of activity-wheel running, rats were decapitated and brains were extracted. Coronal sections were analyzed utilizing in situ hybridization histochemistry for enkephalin (ENK) mRNA in the ventral striatum. RESULTS HCR rats expressed less ENK than LCR rats in the nucleus accumbens among females (p<0.01) and in the olfactory tubercle among both females (p<0.05) and males (p<0.05). There was no effect of wheel running on ENK mRNA expression. CONCLUSIONS Line differences in ENK expression in the olfactory tubercle, and possibly the nucleus accumbens, partly explain divergent wheel-running behavior. The lower striatal ENK in the HCR line is consistent with enhanced dopaminergic tone, which may explain the increased motivation for wheel running observed in the HCR line.

UI MeSH Term Description Entries
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D009714 Nucleus Accumbens Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA. Accumbens Nucleus,Nucleus Accumbens Septi,Accumbens Septi, Nucleus,Accumbens Septus, Nucleus,Accumbens, Nucleus,Nucleus Accumbens Septus,Nucleus, Accumbens,Septi, Nucleus Accumbens,Septus, Nucleus Accumbens
D004745 Enkephalins One of the three major families of endogenous opioid peptides. The enkephalins are pentapeptides that are widespread in the central and peripheral nervous systems and in the adrenal medulla. Enkephalin
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D012420 Running An activity in which the body is propelled by moving the legs rapidly. Running is performed at a moderate to rapid pace and should be differentiated from JOGGING, which is performed at a much slower pace. Runnings
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D066208 Olfactory Tubercle Region in the ventral TELENCEPHALON located anterior to the OPTIC CHIASM, posterior to the OLFACTORY PEDUNCLE, rostral to the PIRIFORM AREA and ventral to the NUCLEUS ACCUMBENS. Anterior Perforated Substance,Anterior Perforated Space,Tuberculum Olfactorium,Anterior Perforated Substances,Olfactorium, Tuberculum,Olfactoriums, Tuberculum,Olfactory Tubercles,Perforated Substance, Anterior,Perforated Substances, Anterior,Substance, Anterior Perforated,Substances, Anterior Perforated,Tubercle, Olfactory,Tubercles, Olfactory,Tuberculum Olfactoriums

Related Publications

Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
December 2001, American journal of physiology. Regulatory, integrative and comparative physiology,
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
January 2014, PloS one,
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
October 2002, Journal of applied physiology (Bethesda, Md. : 1985),
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
February 2013, Physiological genomics,
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
June 2007, American journal of physiology. Endocrinology and metabolism,
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
September 2009, The Journal of experimental biology,
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
January 2013, Connective tissue research,
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
August 2013, American journal of physiology. Endocrinology and metabolism,
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
March 2011, American journal of physiology. Regulatory, integrative and comparative physiology,
Derek C Monroe, and Philip V Holmes, and Lauren G Koch, and Steven L Britton, and Rodney K Dishman
August 2013, American journal of physiology. Heart and circulatory physiology,
Copied contents to your clipboard!