Biomaterial Database

Secretion of protein from salivary glands in the ferret in response to vasoactive intestinal peptide. 1989

J Ekström, and G Tobin

Department of Physiology and Biophysics, Medical Faculty, Lund University, Sweden.

1. Secretory responses of ferret parotid and submandibular glands were investigated in the presence of muscarinic, alpha- and beta-adrenoceptor blocking agents. 2. In pentobarbitone-anaesthetized animals I.V. doses of vasoactive intestinal peptide (VIP) failed to elicit overt secretion of saliva from either gland. 3. However, an occult secretion of protein occurred in response to VIP from both types of gland. This was revealed by means of a subsequent I.V. wash-out injection of substance P, which is a potent secretagogue in ferrets. This effect of VIP was much more marked in the submandibular than in the parotid gland. 4. Electrical stimulation of the chorda-lingual nerve gave rise to protein secretion in the submandibular gland at subthreshold frequencies for overt non-cholinergic, non-adrenergic secretion of saliva, as revealed by subsequent wash-out I.V. injection of substance P. 5. Protein secretion in response to VIP was also demonstrated in vitro by perifusing small pieces of the two glands. The sensitivity of submandibular tissue to VIP greatly exceeded that of the parotid tissue. 6. It is concluded that VIP, or a structurally related peptide, may be involved in the non-cholinergic, non-adrenergic secretory response of ferret salivary glands evoked by parasympathetic nerve stimulation.

UI	MeSH Term	Description	Entries
D010275	Parasympathetic Nervous System	The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.	Nervous System, Parasympathetic,Nervous Systems, Parasympathetic,Parasympathetic Nervous Systems,System, Parasympathetic Nervous,Systems, Parasympathetic Nervous
D010306	Parotid Gland	The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.	Gland, Parotid,Glands, Parotid,Parotid Glands
D002335	Carnivora	An order of MAMMALS, usually flesh eaters with appropriate dentition. Suborders include the terrestrial carnivores Fissipedia, and the aquatic carnivores CANIFORMIA.
D005260	Female		Females
D005289	Ferrets	Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.	Domestic Polecat,Domestic Polecats,European Polecat,European Polecats,Ferret,Mustela putorius,Mustela putorius furo,Polecat, Domestic,Polecat, European,Polecats, Domestic,Polecats, European
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012463	Saliva	The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.	Salivas
D012471	Salivary Proteins and Peptides	Proteins and peptides found in SALIVA and the SALIVARY GLANDS. Some salivary proteins such as ALPHA-AMYLASES are enzymes, but their composition varies in different individuals.	Salivary Gland Protein,Salivary Gland Proteins,Salivary Peptide,Salivary Protein,Salivary Proteins,Salivary Peptides,Gland Protein, Salivary,Peptide, Salivary,Protein, Salivary,Protein, Salivary Gland
D013363	Submandibular Gland	One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)	Submaxillary Gland,Gland, Submandibular,Gland, Submaxillary,Glands, Submandibular,Glands, Submaxillary,Submandibular Glands,Submaxillary Glands
D013373	Substance P	An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.	Euler-Gaddum Substance P,Hypothalamic Substance P,SP(1-11),Euler Gaddum Substance P,Substance P, Euler-Gaddum,Substance P, Hypothalamic