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Liver cells have many functions, and one of which is a production of plasma proteins. Therefore, studies on synthesis and production of plasma proteins from hepatocytes are very important for the recognition of various hepatic dysfunctions, clinically. Of late years, a lot of the complex mechanism of protein synthesis and--secretion was elucidated by using a technique of liver cell culture, for example, primary monolayer culture by freshly isolated hepatocytes and cloned cell culture derived from hepatocellular carcinoma. This paper described the results of our observations and other researchers, and then discussed the point of production of human major plasma proteins using the above culture methods, such as albumin, alpha-fetoprotein and transferrin. Furthermore, we showed statistically that half of twenty-six human hepatoma cell lines established until 1988 in Japan, had already lost their secretory potencies of major plasma proteins in vitro.
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
August 1987,
Biochemical pharmacology,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
January 2003,
Fertility and sterility,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
October 1995,
Current opinion in lipidology,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
November 1987,
The American journal of pathology,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
September 1995,
The American journal of physiology,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
November 1990,
The Journal of clinical endocrinology and metabolism,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
December 1990,
Kidney international,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
April 1999,
World journal of gastroenterology,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
February 1996,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
S Nagamori, and
K Fujise, and
S Hasumura, and
S Homma, and
H Sujino, and
T Matsuura, and
K Shimizu, and
M Niiya, and
H Kameda
May 1982,
The Journal of cell biology,
